Structural determinants of cortical activity propagation
Understanding the mechanisms of the brain, particularly the
cerebral cortex, is our general goal. This theme breaks up into many
detailed problems that still await more definite answers. We believe
that investigating structure/function relationships will provide important
insights into the organization and workings of brain systems. Our experimental
and computational investigations cover both global relationships between
cortical areas (cat, primates) and microcircuitry within a cortical area
(rat barrel cortex).
The methods include: extra- and intracellular slice recordings,
receptor autoradiography, fMRI, multivariate statistical analyses, computational
modeling.
Here are a few examples:
Selected Publications:
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Passingham R.E., Stephan K.E., Kötter R. (2002) The
anatomical basis of functional localization in the cortex. Nature Rev.
Neurosci. 3: 606-616. [pdf
file]
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Stone J.V., Kötter R. (2002) Making connections about
brain connectivity. Trends Cogn. Sci. 6: 327-328. [pdf
file]
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Northoff G., Witzel T., Richter A., Gessner M., Schlagenhauf
F., Fell J., Baumgart F., Kaulisch T., Tempelmann C., Heinzel A., Kötter
R., Hagner T., Bargel B., Hinrichs H., Bogerts B., Scheich H., Heinze H.-J.
(2002) GABA-ergic modulation of prefrontal spatio-temporal activation pattern
during emotional stimulation: a combined fMRI/MEG study with placebo and
lorazepam. J. Cogn. Neurosci. 14: 348-370. [PubMed
abstract]
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Schubert D, Staiger JF, Cho N, Kötter R, Zilles K, Luhmann
HJ (2001) Layer-specific intracolumnar and transcolumnar functional connectivity
of layer V pyramidal cells in rat barrel cortex. J. Neurosci. 21:
3580-3592. [PubMed
abstract]
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Kötter R and Sommer FT (2000) Global relationship between
structural connectivity and activity propagation in the cerebral cortex.
Phil.
Trans. R. Soc. Lond. B 355: 127-134. [PubMed
abstract]
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Northoff G., Richter A., Gessner M., Schlagenhauf F., Stephan
K., Fell J., Baumgart F., Kaulisch T., Kötter R., Leschinger A., Bargel
B., Witzel T., Hinrichs H., Bogerts B., Scheich H., Heinze H.-J. (2000)
Functional dissociation between medial and lateral orbitofrontal cortical
spatiotemporal activation in negative and positive emotions: a combined
FMRI/MEG study. Cereb. Cortex 10: 93-107. [PubMed
abstract]
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Kötter R. (1999) Trends in European computational neuroscience.
Rev.
Neurosci. 10: 175-179. [PubMed
abstract]
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Kötter R., Staiger J.F., Zilles K., Luhmann H.J. (1998)
Analysing functional connectivity in brain slices by a combination of infrared
videomicroscopy, flash photolysis of caged compounds and scanning methods.
Neuroscience
86: 265-277. [PubMed
abstract]
Rolf Kötter,
02/2003